2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Xanthine Oxidase

Xanthine Oxidase

XO

Xanthine Oxidase

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Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14268R
    Febuxostat (Standard)
    		Inhibitor
    Febuxostat (Standard) is the analytical standard of Febuxostat. This product is intended for research and analytical applications. Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout.
    Febuxostat (Standard)
  • HY-B0219R
    Allopurinol (Standard)
    		Inhibitor
    Allopurinol (Standard) is the analytical standard of Allopurinol. This product is intended for research and analytical applications. Allopurinol is a potent and orally active xanthine oxidase inhibitor with an IC50 value of 0.2-50 μM. Allopurinol can be used in the research of hyperuricemia and gout. Allopurinol decreases the expression of HIF-1α and HIF-2α protein. Allopurinol shows anti-depressant and anti-nociception activity. Anti-leishmanial effect.
    Allopurinol (Standard)
  • HY-N1547R
    Prudomestin (Standard)
    		Inhibitor
    Prudomestin (Standard) is the analytical standard of Prudomestin. This product is intended for research and analytical applications. Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6?μM).
    Prudomestin (Standard)
  • HY-B1135R
    Benzbromarone (Standard)
    		Inhibitor
    Benzbromarone (Standard) is the analytical standard of Benzbromarone. This product is intended for research and analytical applications. Benzbromarone is an orally active anti-gout agent. Benzbromarone has anti-infammatory, anti-oxidative stress and nephroprotective effects. Benzbromarone can be used for the research of hyperuricemia and gout.
    Benzbromarone (Standard)
  • HY-W015069
    4-Nitrocinnamic acid
    		Inhibitor 99.88%
    4-Nitrocinnamic acid is a Phenylpropanoids product that can be isolated from the heartwoods of Cassia garrettiana.
    4-Nitrocinnamic acid
  • HY-14874R
    Topiroxostat (Standard)
    		Inhibitor
    Topiroxostat (Standard) is the analytical standard of Topiroxostat. This product is intended for research and analytical applications. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.
    Topiroxostat (Standard)
  • HY-19164
    BOF-4272
    		Inhibitor
    BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor. BOF-4272 can be used for hyperuricemia research.
    BOF-4272
  • HY-19657R
    Oxypurinol (Standard)
    		Inhibitor
    Oxypurinol (Standard) is the analytical standard of Oxypurinol. This product is intended for research and analytical applications. Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
    Oxypurinol (Standard)
  • HY-119955
    Amflutizole
    		Inhibitor
    Amflutizole (LY-141894) is an inhibitor of xanthine oxidase. Amflutizole abolishes free radical formation and release in cerebral ischemia/reperfusion mice.
    Amflutizole
  • HY-W560574
    Xanthine oxidase-IN-14
    		Inhibitor
    Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC50 >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC50 greater than 150 μM.
    Xanthine oxidase-IN-14
  • HY-W777649
    Oxypurinol-13C,15N2-1
    		Inhibitor
    Oxypurinol-13C,15N2-1 (Oxipurinol-13C,15N2-1) is 15N and 13C labeled Oxypurinol (HY-19657). Oxipurinol, the major active metabolite of Allopurinoll (HY-B0219), is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
    Oxypurinol-<sup>13</sup>C,<sup>15</sup>N<sub>2</sub>-1
  • HY-116433R
    Nequinate (Standard)
    		Inhibitor
    Nequinate (Standard) is the analytical standard of Nequinate. This product is intended for research and analytical applications. Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.
    Nequinate (Standard)
  • HY-U00288
    Xanthine oxidase-IN-1
    		Inhibitor
    Xanthine oxidase-IN-1 is a xanthine oxidase inhibitor extracted from patent WO2008126898A1, page 68, compound example 3, with an IC50 of 6.5 nM.
    Xanthine oxidase-IN-1
Cat. No. Product Name / Synonyms Application Reactivity